category
Nature Communications
date
Feb 21, 2026
slug
status
Published
summary
通过设计蛋白聚集体的不对称遗传机制,首次在大肠杆菌中实现可控的线性生长模式,突破微生物天然指数增殖的生物学限制。
tags
合成生物学
type
Post

📄 原文题目

Engineering non-exponential proliferation in <i>Escherichia coli</i> using functionalized protein aggregates

🔗 原文链接

💡 AI 核心解读

通过设计蛋白聚集体的不对称遗传机制,首次在大肠杆菌中实现可控的线性生长模式,突破微生物天然指数增殖的生物学限制。

📝 英文原版摘要

<p>Nature Communications, Published online: 21 February 2026; <a href="https://www.nature.com/articles/s41467-026-69334-y">doi:10.1038/s41467-026-69334-y</a></p>Microbes naturally grow exponentially, but linear growth may be desirable for some therapeutic applications of genetically modified microorganisms. Here the authors engineered linear growth in E. coli by making division dependent on the asymmetric inheritance of a protein aggregate.
解码弓头鲸的DNA修复工具包KRAB锌指蛋白在扩展转座元件驯化潜力中的作用
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