category
Nature Communications
date
Mar 21, 2026
slug
status
Published
summary
通过超生理水平激活L-组氨酸生物合成途径，利用营养和能量耗竭机制抑制结核分枝杆菌生长，为抗生素开发提供全新代谢调控策略
tags
合成生物学
type
Post
📄 原文题目
Activation of <span>l</span>-histidine biosynthesis as a new antibiotic strategy against <i>Mycobacterium tuberculosis</i>
🔗 原文链接
💡 AI 核心解读
通过超生理水平激活L-组氨酸生物合成途径，利用营养和能量耗竭机制抑制结核分枝杆菌生长，为抗生素开发提供全新代谢调控策略
📝 英文原版摘要
<p>Nature Communications, Published online: 21 March 2026; <a href="https://www.nature.com/articles/s41467-026-70510-3">doi:10.1038/s41467-026-70510-3</a></p>Here, the authors report metabolic activation as a potential antimicrobial strategy against Mycobacterium tuberculosis. They show that supra-physiological activation of L-histidine biosynthesis reduces bacterial growth and causes loss of fitness due to nutrient and energy depletion.
- 作者:NotionNext
- 链接:https://tangly1024.com/article/32a48bd6-1f96-8143-92f5-ce1f74b4b9e9
- 声明:本文采用 CC BY-NC-SA 4.0 许可协议，转载请注明出处。
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