category
PNAS
date
Feb 4, 2026
slug
status
Published
summary
通过酿酒酵母高通量筛选发现DNA修复过程存在显著高于正常复制的突变率，揭示了同源重组修复机制中固有的错误倾向，并系统解析了结构变异的形成规律。
tags
测序技术
type
Post
📄 原文题目
Mutations and structural variants arising during double-strand break repair
🔗 原文链接
💡 AI 核心解读
通过酿酒酵母高通量筛选发现DNA修复过程存在显著高于正常复制的突变率，揭示了同源重组修复机制中固有的错误倾向，并系统解析了结构变异的形成规律。
📝 英文原版摘要
Proceedings of the National Academy of Sciences, Volume 123, Issue 6, February 2026. <br />SignificanceDNA synthesis during repair of a double-strand chromosome break by homologous recombination exhibits a high rate of mutation compared to normal replication. Using budding yeast, we isolated thousands of mutations occurring during repair. We ...
- 作者:NotionNext
- 链接:https://tangly1024.com/article/30548bd6-1f96-81b4-a234-c3853f8c4ddf
- 声明:本文采用 CC BY-NC-SA 4.0 许可协议，转载请注明出处。
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