<p>Nature Genetics, Published online: 24 February 2026; <a href="https://www.nature.com/articles/s41588-026-02519-9">doi:10.1038/s41588-026-02519-9</a></p>In this issue, Jiang et al. introduce a proteomic method called LoopID and show that JMJD2 demethylases have a non-catalytic role in promoting enhancer–promoter looping in mouse embryonic stem cells. This function is mediated by their intrinsically disordered domains, suggesting a condensate-based mechanism.