category
Nature Communications
date
Mar 2, 2026
slug
status
Published
summary
首次通过氢/氘交换质谱与溶液核磁共振联用技术，揭示了Bpa的组装动态及其与底物的相互作用机制，填补了该蛋白结构异质性研究的空白。
tags
蛋白质组学
type
Post
📄 原文题目
Structural heterogeneity and substrate engagement mechanism of the bacterial proteasome activator Bpa
🔗 原文链接
💡 AI 核心解读
首次通过氢/氘交换质谱与溶液核磁共振联用技术，揭示了Bpa的组装动态及其与底物的相互作用机制，填补了该蛋白结构异质性研究的空白。
📝 英文原版摘要
<p>Nature Communications, Published online: 02 March 2026; <a href="https://www.nature.com/articles/s41467-026-69978-w">doi:10.1038/s41467-026-69978-w</a></p>Bpa (bacterial proteasome activator) is essential for Mycobacterium tuberculosis virulence, yet its structural heterogeneity and mode of substrate engagement have remained poorly understood. Here, the authors combine hydrogen/deuterium exchange mass spectrometry and solution NMR spectroscopy to elucidate Bpa assembly and its interaction with a model substrate.
- 作者:NotionNext
- 链接:https://tangly1024.com/article/31748bd6-1f96-8152-a57d-c398d350e670
- 声明:本文采用 CC BY-NC-SA 4.0 许可协议，转载请注明出处。
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