category
PNAS
date
Feb 26, 2026
slug
status
Published
summary
首次揭示Rabankyrin-5通过调控内体融合过程,为HPV病毒提供关键的细胞内运输通道,阐明病毒劫持宿主内体网络的新机制
tags
蛋白质组学
type
Post

📄 原文题目

The Rab5 effector Rabankyrin-5 mediates endosomal fusion and trafficking of human papillomavirus during early entry

🔗 原文链接

💡 AI 核心解读

首次揭示Rabankyrin-5通过调控内体融合过程,为HPV病毒提供关键的细胞内运输通道,阐明病毒劫持宿主内体网络的新机制

📝 英文原版摘要

Proceedings of the National Academy of Sciences, Volume 123, Issue 9, March 2026. <br />SignificanceAfter endocytosis, newly formed early endosomes fuse to generate larger early endosomes, which subsequently mature into late endosomes. Many viruses exploit this pathway to hijack the endosomal network and reach intracellular replication ...
残留的GET通路因子进化重塑为PEX38,一种必需的过氧化物酶从肽到DNA:所有必要步骤均可被催化
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