category
Nature Communications
date
Mar 6, 2026
slug
status
Published
summary
揭示了CCDC6-RET融合蛋白的自激活机制，发现其活性同时依赖ATP和ADP，为癌症信号传导研究提供新视角
tags
蛋白质组学
type
Post
📄 原文题目
The oncogenic CCDC6-RET fusion protein is a dual ATP- and ADP-dependent kinase
🔗 原文链接
💡 AI 核心解读
揭示了CCDC6-RET融合蛋白的自激活机制，发现其活性同时依赖ATP和ADP，为癌症信号传导研究提供新视角
📝 英文原版摘要
<p>Nature Communications, Published online: 06 March 2026; <a href="https://www.nature.com/articles/s41467-026-69833-y">doi:10.1038/s41467-026-69833-y</a></p>Gene fusion products involving protein kinases are known drivers in human cancers and actionable targets for personalized therapy. Here, the authors uncover the structural and molecular determinants that control the mechanism of autoactivation of the CCDC6-RET oncogenic fusion protein revealing a dual ATP and ADP dependent activity, with implications in cancer signaling.
- 作者:NotionNext
- 链接:https://tangly1024.com/article/31b48bd6-1f96-8134-b788-e2d4a6b55187
- 声明:本文采用 CC BY-NC-SA 4.0 许可协议，转载请注明出处。
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