category
bioRxiv
date
Mar 10, 2026
slug
status
Published
summary
创新性地利用DNA折纸技术构建磁性纳米马达,实现单分子级别可控旋转和磁力夹持;通过调节纳米立方体排列密度和间距,获得10-100 pN nm量级磁扭矩;结合蒙特卡洛模拟揭示纳米立方体组装后的集体磁性特性,为生物相容性纳米机器人和高通量磁力操控技术奠定基础。
tags
合成生物学
type
Post
📄 原文题目
Magnetic DNA Origami Nanorotors
🔗 原文链接
💡 AI 核心解读
创新性地利用DNA折纸技术构建磁性纳米马达,实现单分子级别可控旋转和磁力夹持;通过调节纳米立方体排列密度和间距,获得10-100 pN nm量级磁扭矩;结合蒙特卡洛模拟揭示纳米立方体组装后的集体磁性特性,为生物相容性纳米机器人和高通量磁力操控技术奠定基础。
📝 英文原版摘要
Self-assembled DNA nanostructures show great promise as functional devices, highly configurable materials, and in nanorobotics. Magnetic control can provide a powerful actuation mechanism in a broad range of contexts, since it affords a high-level of external control, it is biocompatible, and orthogonal to chemical or electrical stimuli. Here we demonstrate magnetic molecular nanoactuators by leveraging the unique site-specificity of DNA origami to assemble highly anisotropic magnetic nanocubes on high-aspect ratio DNA origami bundles. We traced and controlled 100s of our DNA origami nanorotors at the single-rotor level and demonstrated their programmable magnetic clamping and controlled rotation under uniform and rotating magnetic fields. By varying the population and inter-particle spacing of the nanocubes, magnetic torque values in the order of 10-100 pN nm are achieved at field strengths < 10 mT. Monte Carlo simulations reveal that assembly of nanocubes on DNA origami rotors leads to collective magnetic properties, with numerically estimated torque values in good agreement with the experiments. Our magnetic nanorotors offer a foundation for biocompatible nanorobotics, as well as high-throughput magnetic force and torque tweezers.
- 作者:NotionNext
- 链接:https://tangly1024.com/article/31f48bd6-1f96-8146-b326-efc7695393cb
- 声明:本文采用 CC BY-NC-SA 4.0 许可协议,转载请注明出处。
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