category
PNAS
date
Mar 2, 2026
slug
status
Published
summary
开发了受体介导的内溶酶体回收嵌合体（RECYC）技术，通过多周期降解免疫检查点动态重塑肿瘤免疫微环境中的抑制性网络，克服现有免疫检查点抑制剂的治疗局限性。
tags
合成生物学
抗体核酸偶联
type
Post
📄 原文题目
Dynamic reprogramming of the tumor immune network via multicycle checkpoint degradation for cancer immunotherapy
🔗 原文链接
💡 AI 核心解读
开发了受体介导的内溶酶体回收嵌合体（RECYC）技术，通过多周期降解免疫检查点动态重塑肿瘤免疫微环境中的抑制性网络，克服现有免疫检查点抑制剂的治疗局限性。
📝 英文原版摘要
Proceedings of the National Academy of Sciences, Volume 123, Issue 10, March 2026. <br />SignificanceImmune checkpoint inhibitors often fail because suppressive checkpoint-linked networks span tumor and myeloid compartments in the tumor immune microenvironment (TIME). We developed Receptormediated Endolysosomal recYcling Chimera (RECYC), a ...
- 作者:NotionNext
- 链接:https://tangly1024.com/article/32248bd6-1f96-81b9-a322-cdd932dd244b
- 声明:本文采用 CC BY-NC-SA 4.0 许可协议，转载请注明出处。
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