category
Nature Microbiology
date
Mar 16, 2026
slug
status
Published
summary
发现早产儿梭菌株通过代谢人乳低聚糖产生特定代谢物，可促进双歧杆菌增殖、抑制病原体并减轻炎症，揭示了肠道微生物代谢调控宿主免疫的新机制。
tags
基因编辑
type
Post
📄 原文题目
Clostridia from preterm infants metabolize human milk oligosaccharides to suppress pathobionts and modulate intestinal function in organoids
🔗 原文链接
💡 AI 核心解读
发现早产儿梭菌株通过代谢人乳低聚糖产生特定代谢物，可促进双歧杆菌增殖、抑制病原体并减轻炎症，揭示了肠道微生物代谢调控宿主免疫的新机制。
📝 英文原版摘要
<p>Nature Microbiology, Published online: 16 March 2026; <a href="https://www.nature.com/articles/s41564-026-02297-4">doi:10.1038/s41564-026-02297-4</a></p>Clostridium perfringens lacking perfringolysin O toxin isolated from preterm infants metabolizes human milk oligosaccharide disialyllacto-N-tetraose to produce metabolites that promote the growth of commensal bifidobacteria, inhibit pathogens and suppress inflammation in an organoid model.
- 作者:NotionNext
- 链接:https://tangly1024.com/article/32548bd6-1f96-812a-a4fe-db909d5bf0fb
- 声明:本文采用 CC BY-NC-SA 4.0 许可协议，转载请注明出处。
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