category
bioRxiv
date
Mar 17, 2026
slug
status
Published
summary
提出st-Xprop方法,通过构建模态特定图和交替跨模态传播,整合基因表达与组织学图像的异构模态数据;利用双图嵌入耦合学习统一低维表示,提升空间域识别的稳定性与生物学意义。
tags
空间组学
type
Post
📄 原文题目
Cross-Propagative Graph Learning Reveals Spatial Tissue Domains in Multi-Modal Spatial Transcriptomics
🔗 原文链接
💡 AI 核心解读
提出st-Xprop方法,通过构建模态特定图和交替跨模态传播,整合基因表达与组织学图像的异构模态数据;利用双图嵌入耦合学习统一低维表示,提升空间域识别的稳定性与生物学意义。
📝 英文原版摘要
Spatial transcriptomics enables in situ characterization of tissue organization by jointly profiling gene expression profiles and spatial coordinates, with histological images as complementary contextual information. However, effectively integrating these heterogeneous modalities remains challenging due to differences in statistical properties and structural patterns. We propose st-Xprop, a cross-propagative graph network with dual-graph embedding coupling for spatial domain identification. st-Xprop constructs modality-specific graphs for gene expression and histological features, and performs alternating cross-modal propagation to explicitly model inter-modal heterogeneity while enabling complementary information exchange. Through dual-graph embedding coupling, the framework progressively learns a unified low-dimensional representation that integrates multimodal signals and preserves spatial coherence. Evaluations on multiple real spatial transcriptomics datasets demonstrate that st-Xprop consistently improves clustering accuracy and robustness, particularly in weak-signal or structurally complex regions, yielding spatial domains that are more stable and biologically meaningful.
- 作者:NotionNext
- 链接:https://tangly1024.com/article/32648bd6-1f96-8174-9625-c39724ed28dc
- 声明:本文采用 CC BY-NC-SA 4.0 许可协议,转载请注明出处。
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