category
Nature Biotechnology
date
Mar 18, 2026
slug
status
Published
summary
构建携带合成精氨酸-一氧化氮（NO）回路的工程化大肠杆菌菌株，通过持续肿瘤内NO生成实现血管正常化和免疫重编程，与PD-L1免疫检查点阻断协同激活CD8+ T细胞，诱导持久肿瘤消退。
tags
合成生物学
基因编辑
type
Post
📄 原文题目
An engineered <i>E. coli</i> strain sustains intratumoral nitric oxide production to boost effectiveness of tumor immunotherapy
🔗 原文链接
💡 AI 核心解读
构建携带合成精氨酸-一氧化氮（NO）回路的工程化大肠杆菌菌株，通过持续肿瘤内NO生成实现血管正常化和免疫重编程，与PD-L1免疫检查点阻断协同激活CD8+ T细胞，诱导持久肿瘤消退。
📝 英文原版摘要
<p>Nature Biotechnology, Published online: 18 March 2026; <a href="https://www.nature.com/articles/s41587-026-03055-x">doi:10.1038/s41587-026-03055-x</a></p>An engineered Escherichia coli Nissle 1917 strain carrying a synthetic arginine–nitric oxide (NO) circuit enables sustained intratumoral NO production that promotes vascular normalization and immune reprogramming. This reshaped tumor microenvironment synergizes with blockade of the immune checkpoint PD-L1 to reinvigorate CD8+ T cells and drive durable tumor regression in mouse models.
- 作者:NotionNext
- 链接:https://tangly1024.com/article/32748bd6-1f96-81b9-b241-e4374b37a8da
- 声明:本文采用 CC BY-NC-SA 4.0 许可协议，转载请注明出处。
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