category
Molecular Cell
date
Mar 4, 2026
slug
status
Published
summary
发现PRC2复合物的辅助亚基JARID2和PALI1通过结构模拟H3K27me3修饰，拮抗PRC2自身催化活性，从而精确控制Polycomb结构域的扩散范围，确保发育基因在正确时空激活。
tags
蛋白质组学
type
Post
📄 原文题目
Accessory subunits of PRC2 mimic H3K27me3 to restrict the spread of Polycomb domains
🔗 原文链接
💡 AI 核心解读
发现PRC2复合物的辅助亚基JARID2和PALI1通过结构模拟H3K27me3修饰，拮抗PRC2自身催化活性，从而精确控制Polycomb结构域的扩散范围，确保发育基因在正确时空激活。
📝 英文原版摘要
Some proteins mimic the repressive mark H3K27me3, but the physiological relevance of this phenomenon was unclear. Agius et al. show that the PRC2 subunits JARID2 and PALI1 mimic H3K27me3 to antagonize PRC2-mediated H3K27me3 deposition, limit Polycomb domain spreading, and enable timely activation of developmental genes in vivo.
- 作者:NotionNext
- 链接:https://tangly1024.com/article/32848bd6-1f96-813e-9c75-ccda9b8036be
- 声明:本文采用 CC BY-NC-SA 4.0 许可协议，转载请注明出处。
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