category
PNAS
date
Mar 13, 2026
slug
status
Published
summary
研究揭示了tau冷凝物老化过程中可逆性与β-折叠形成解耦的机制,为阿尔茨海默病的治疗提供了新的潜在靶点。
tags
蛋白质组学
type
Post

📄 原文题目

Reversibility and β-sheet formation are decoupled in tau condensate aging

🔗 原文链接

💡 AI 核心解读

研究揭示了tau冷凝物老化过程中可逆性与β-折叠形成解耦的机制,为阿尔茨海默病的治疗提供了新的潜在靶点。

📝 英文原版摘要

Proceedings of the National Academy of Sciences, Volume 123, Issue 11, March 2026. <br />SignificanceAn aberrant phase transition of tau protein into insoluble protein aggregates is implicated in Alzheimer’s disease. Growing evidence suggests that early tau aggregation can be mediated by biomolecular condensates. However, the process by which ...
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