category
PNAS
date
Mar 16, 2026
slug
status
Published
summary
创新性地利用特异性浸润肿瘤的效应细胞作为毒素递送载体,通过局部释放致命毒素实现精准抗癌,显著降低系统性给药导致的全身毒性风险。
tags
合成生物学
抗体核酸偶联
type
Post

📄 原文题目

Lethal toxin–equipped effector cells for the potential treatment of cancer

🔗 原文链接

💡 AI 核心解读

创新性地利用特异性浸润肿瘤的效应细胞作为毒素递送载体,通过局部释放致命毒素实现精准抗癌,显著降低系统性给药导致的全身毒性风险。

📝 英文原版摘要

Proceedings of the National Academy of Sciences, Volume 123, Issue 12, March 2026. <br />Lethal toxins could become potent therapies against cancer, but their clinical utility is limited by adverse events upon systemic administration. These could be reduced if the toxins were delivered by effector cells that specifically infiltrate cancers, ...
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