category
Nature Communications
date
Feb 18, 2026
slug
status
Published
summary
发现TWIST1蛋白通过促进内皮细胞可塑性，既推动动脉粥样硬化斑块生长，又增强其稳定性并降低破裂风险，颠覆了传统认为细胞转化必然恶化疾病的认知。
tags
蛋白质组学
type
Post
📄 原文题目
TWIST1 drives endothelial-to-mesenchymal-transition to stabilize atherosclerotic plaques
🔗 原文链接
💡 AI 核心解读
发现TWIST1蛋白通过促进内皮细胞可塑性，既推动动脉粥样硬化斑块生长，又增强其稳定性并降低破裂风险，颠覆了传统认为细胞转化必然恶化疾病的认知。
📝 英文原版摘要
<p>Nature Communications, Published online: 18 February 2026; <a href="https://www.nature.com/articles/s41467-026-69808-z">doi:10.1038/s41467-026-69808-z</a></p>Endothelial-to-mesenchymal transition contributes to plaque progression in atherosclerosis. Here, Ayllon et al. show that the protein TWIST1 drives endothelial cell plasticity in atherosclerosis, promoting plaque growth and stability while reducing features linked to rupture, challenging the view that these cell changes always worsen disease.
- 作者:NotionNext
- 链接:https://tangly1024.com/article/30b48bd6-1f96-8195-82fa-eae8104db031
- 声明:本文采用 CC BY-NC-SA 4.0 许可协议，转载请注明出处。
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