category
Nature
date
Feb 18, 2026
slug
status
Published
summary
发现CloA和CloB通过特定核苷酸信号（dTTP和5′-triphosphothymidyl-3′5′-thymidine）动态调控细菌免疫平衡，揭示了抗病毒防御与免疫毒性之间的分子开关机制。
tags
核酸蛋白工具酶
type
Post
📄 原文题目
Nucleotide signals coordinate activation and inhibition of bacterial immunity
🔗 原文链接
💡 AI 核心解读
发现CloA和CloB通过特定核苷酸信号（dTTP和5′-triphosphothymidyl-3′5′-thymidine）动态调控细菌免疫平衡，揭示了抗病毒防御与免疫毒性之间的分子开关机制。
📝 英文原版摘要
<p>Nature, Published online: 18 February 2026; <a href="https://www.nature.com/articles/s41586-026-10135-0">doi:10.1038/s41586-026-10135-0</a></p>Biochemical and structural studies show that the bacterial dGTPase CloA is activated by virally produced dTTP and inhibited by 5′-triphosphothymidyl-3′5′-thymidine produced by its regulatory partner CloB, and thereby balances antiviral defence and immune-mediated toxicity.
- 作者:NotionNext
- 链接:https://tangly1024.com/article/30c48bd6-1f96-8162-a4f7-c6121ac7c64a
- 声明:本文采用 CC BY-NC-SA 4.0 许可协议，转载请注明出处。
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