category
PNAS
date
Feb 9, 2026
slug
status
Published
summary
创新性地整合蛋白质语言模型与结构上下文信息,开发AI框架提升赖氨酸翻译后修饰位点预测的准确性
tags
蛋白质组学
type
Post

📄 原文题目

Mining lysine post-translational modification sites by integrating protein language model representations with structural context

🔗 原文链接

💡 AI 核心解读

创新性地整合蛋白质语言模型与结构上下文信息,开发AI框架提升赖氨酸翻译后修饰位点预测的准确性

📝 英文原版摘要

Proceedings of the National Academy of Sciences, Volume 123, Issue 7, February 2026. <br />SignificanceLysine post-translational modifications (PTMs) are crucial for regulating protein function, yet their experimental identification remains challenging. To address this, we developed an AI framework that uniquely integrates protein sequence ...
甲硫氨酸特异性不可逆生物偶联:推进精准蛋白质修饰肠道细菌中糖原磷酸化酶的结构和机制多样性
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