category
PNAS
date
Feb 18, 2026
slug
status
Published
summary
通过非侵入性液体活检(血浆/尿液DNA监测)评估肿瘤动态,为肌层浸润性膀胱癌患者提供保留膀胱的个体化治疗决策依据,减少根治性膀胱切除术带来的生活质量损害。
tags
测序技术
type
Post

📄 原文题目

Monitoring of plasma and urine tumor-derived DNA to inform bladder-sparing approaches for patients with muscle-invasive bladder cancer

🔗 原文链接

💡 AI 核心解读

通过非侵入性液体活检(血浆/尿液DNA监测)评估肿瘤动态,为肌层浸润性膀胱癌患者提供保留膀胱的个体化治疗决策依据,减少根治性膀胱切除术带来的生活质量损害。

📝 英文原版摘要

Proceedings of the National Academy of Sciences, Volume 123, Issue 8, February 2026. <br />SignificanceRadical cystectomy—surgical removal of the bladder and creation of permanent urinary diversion—has historically been used to treat muscle-invasive bladder cancer, but is life-altering with permanent changes to urinary function, sexuality, and ...
CDKL5通过液-液相分离调节兴奋性突触的可塑性营养基因组学分析鉴定ZIP10(SLC39A10)为红细胞锌稳态的调节因子,并与贫血风险的遗传关联
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