category
PNAS
date
Feb 23, 2026
slug
status
Published
summary
发现核膜蛋白NEMP1通过与Nesprin形成复合物,在机械转导过程中发挥关键作用,揭示了细胞感知和响应基质力学信号的新机制。
tags
蛋白质组学
type
Post

📄 原文题目

The Nemp1–Nesprin complex mediates cellular responses to matrix mechanics

🔗 原文链接

💡 AI 核心解读

发现核膜蛋白NEMP1通过与Nesprin形成复合物,在机械转导过程中发挥关键作用,揭示了细胞感知和响应基质力学信号的新机制。

📝 英文原版摘要

Proceedings of the National Academy of Sciences, Volume 123, Issue 9, March 2026. <br />SignificanceWe found that the Nuclear Envelope Membrane Protein 1 (NEMP1) is vital for cell survival under various mechanical stresses, introducing a player in mechanotransduction; the process by which cells convert mechanical signals into biochemical ...
神经元TDP-43通过稳定neurexin 1 mRNA调节髓鞘形成抗活性氧超稳定超分辨率DNA框架点
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