<p>Nature Genetics, Published online: 23 March 2026; <a href="https://www.nature.com/articles/s41588-026-02555-5">doi:10.1038/s41588-026-02555-5</a></p>Bu using organ-wide single-cell MERFISH, researchers create a spatial atlas of healthy human skin and identify distinct site-specific cellular compositions. This work emphasize the importance of skin organization, from molecular architecture to anatomical scales, in maintaining skin homeostasis and influencing patterns of disease.