category
PNAS
date
Feb 27, 2026
slug
status
Published
summary
开发了适用于大规模生物库的稀有变异关联检验方法，解决了现有方法在时间至事件表型分析中的局限性，实现了准确性和可扩展性的平衡。
tags
测序技术
type
Post
📄 原文题目
Scalable and accurate rare-variant association tests for whole genome sequencing time-to-event analysis in large biobanks
🔗 原文链接
💡 AI 核心解读
开发了适用于大规模生物库的稀有变异关联检验方法，解决了现有方法在时间至事件表型分析中的局限性，实现了准确性和可扩展性的平衡。
📝 英文原版摘要
Proceedings of the National Academy of Sciences, Volume 123, Issue 9, March 2026. <br />SignificanceRare variants (RV) identified through whole genome sequencing hold great promise for elucidating the genetic basis of disease onset, but existing methods for RV association testing are not well suited for time-to-event phenotypes. Here, we ...
- 作者:NotionNext
- 链接:https://tangly1024.com/article/31948bd6-1f96-8110-b119-f11fa2b24b7f
- 声明:本文采用 CC BY-NC-SA 4.0 许可协议，转载请注明出处。
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