category
Molecular Cell
date
Feb 26, 2026
slug
status
Published
summary
开发了优化的CRISPR平台，整合敲除、敲低和Perturb-seq多组学筛选方法，首次在患者来源细胞中直接解析癌症脆弱性和细胞异质性
tags
基因编辑
单细胞测序
type
Post
📄 原文题目
CRISPR-based functional genomics for dissecting therapeutic dependency in primary acute myeloid leukemia samples
🔗 原文链接
💡 AI 核心解读
开发了优化的CRISPR平台，整合敲除、敲低和Perturb-seq多组学筛选方法，首次在患者来源细胞中直接解析癌症脆弱性和细胞异质性
📝 英文原版摘要
Direct CRISPR functional genomics in primary patient samples holds promise for therapeutic target validation and discovery. Cao et al. develop an optimized CRISPR platform for genetic screening in primary acute myeloid leukemia samples. Integrated knockout, knockdown, and Perturb-seq screens dissect cancer vulnerabilities and cellular heterogeneity directly in patient-derived cells.
- 作者:NotionNext
- 链接:https://tangly1024.com/article/31b48bd6-1f96-8131-bc57-d417f8f2663e
- 声明:本文采用 CC BY-NC-SA 4.0 许可协议，转载请注明出处。
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