category
Molecular Cell
date
Feb 16, 2026
slug
status
Published
summary
开发circTargetMap计算框架实现全转录组环状RNA-靶标RNA互作映射，发现环状RNA通过碱基配对将mRNA隔离至P体实现翻译抑制，且该机制独立于miRNA，揭示环状RNA在疾病中的翻译调控新机制。
tags
测序技术
type
Post
📄 原文题目
Global mapping of circRNA-target RNA interactions reveal P-body-mediated translational repression
🔗 原文链接
💡 AI 核心解读
开发circTargetMap计算框架实现全转录组环状RNA-靶标RNA互作映射，发现环状RNA通过碱基配对将mRNA隔离至P体实现翻译抑制，且该机制独立于miRNA，揭示环状RNA在疾病中的翻译调控新机制。
📝 英文原版摘要
Li et al. introduce circTargetMap, a computational framework for transcriptome-wide mapping of circRNA-target RNA interactions using RIC-seq data. They show that circRNAs such as CDR1as repress mRNA translation by base-pairing-mediated sequestration into P-bodies, independent of miRNAs, revealing a general mode of circRNA-mediated translational regulation with disease relevance.
- 作者:NotionNext
- 链接:https://tangly1024.com/article/31b48bd6-1f96-8154-acbe-c2ac2a9f2b4f
- 声明:本文采用 CC BY-NC-SA 4.0 许可协议，转载请注明出处。
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