category
Nature Communications
date
Mar 6, 2026
slug
status
Published
summary
发现USP7通过稳定FAN1促进DNA交联修复，抑制CAG重复序列扩展，为遗传性疾病的治疗提供新靶点。
tags
蛋白质组学
核酸蛋白工具酶
type
Post
📄 原文题目
USP7 deubiquitinase stabilizes FAN1 to support DNA crosslink repair and suppress CAG repeat expansion
🔗 原文链接
💡 AI 核心解读
发现USP7通过稳定FAN1促进DNA交联修复，抑制CAG重复序列扩展，为遗传性疾病的治疗提供新靶点。
📝 英文原版摘要
<p>Nature Communications, Published online: 06 March 2026; <a href="https://www.nature.com/articles/s41467-026-70051-9">doi:10.1038/s41467-026-70051-9</a></p>FAN1 is a DNA repair enzyme that maintains genome stability and limits repeat expansions linked to Huntington’s disease. Here, the authors show that USP7 stabilizes FAN1, supporting DNA repair, protecting cells from DNA damage, and slowing CAG repeat expansion.
- 作者:NotionNext
- 链接:https://tangly1024.com/article/31b48bd6-1f96-81a5-9783-fbc44661f54c
- 声明:本文采用 CC BY-NC-SA 4.0 许可协议，转载请注明出处。
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