<p>Nature Communications, Published online: 10 March 2026; <a href="https://www.nature.com/articles/s41467-026-70451-x">doi:10.1038/s41467-026-70451-x</a></p>Given the interest in extracellular vesicles there is a need for simple short scaffold proteins for efficient targeting and cargo loading. Here, the authors identify a candidate scaffold protein and find the truncated version allows for efficient loading which outperforms current scaffold proteins, demonstrating application in sepsis therapy.