category
PNAS
date
Mar 4, 2026
slug
status
Published
summary
揭示了PI(4,5)P2通过促进Arl4D自相互作用调控Pak1信号通路的新机制，阐明了膜脂与小GTP酶协同调控细胞迁移的分子基础。
tags
蛋白质组学
type
Post
📄 原文题目
Phosphatidylinositol 4,5-bisphosphate mediates Arl4D self-interaction to promote Pak1 signaling
🔗 原文链接
💡 AI 核心解读
揭示了PI(4,5)P2通过促进Arl4D自相互作用调控Pak1信号通路的新机制，阐明了膜脂与小GTP酶协同调控细胞迁移的分子基础。
📝 英文原版摘要
Proceedings of the National Academy of Sciences, Volume 123, Issue 10, March 2026. <br />SignificanceWe show how self-association of the small GTPase Arl4D on membrane is achieved for intracellular signaling that leads to cell migration. This self-association requires the cooperative action of Arl4D binding to a critical lipid, PI(4,5)P2, and ...
- 作者:NotionNext
- 链接:https://tangly1024.com/article/32248bd6-1f96-81e1-ba14-d635f5ac3fd8
- 声明:本文采用 CC BY-NC-SA 4.0 许可协议，转载请注明出处。
相关文章