<p>Nature Communications, Published online: 12 February 2026; <a href="https://www.nature.com/articles/s41467-026-69090-z">doi:10.1038/s41467-026-69090-z</a></p>CRISPR/Cas9 screens have identified genetic contributions to many phenotypes. However, studying combinations of genes or regulatory elements remains challenging. Here, the authors use CRISPR/Cas12a to overcome those challenges and enable new approaches to study combinatorial genetic mechanisms.