category
Nature Communications
date
Mar 7, 2026
slug
status
Published
summary
该研究通过单细胞RNA测序技术，首次揭示了IL-33-ST2-OPN信号轴在血管周围间质细胞与ST2+修复性巨噬细胞之间的功能交互作用，阐明了其在血管损伤后内膜增生中的促进作用机制。
tags
单细胞测序
type
Post
📄 原文题目
Perivascular mesenchymal cells instruct ST2+ reparative macrophages to promote endovascular injury-induced neointimal hyperplasia in mice
🔗 原文链接
💡 AI 核心解读
该研究通过单细胞RNA测序技术，首次揭示了IL-33-ST2-OPN信号轴在血管周围间质细胞与ST2+修复性巨噬细胞之间的功能交互作用，阐明了其在血管损伤后内膜增生中的促进作用机制。
📝 英文原版摘要
<p>Nature Communications, Published online: 07 March 2026; <a href="https://www.nature.com/articles/s41467-026-68587-x">doi:10.1038/s41467-026-68587-x</a></p>Mesenchymal stromal cells (MSC) contribute to tissue repair and regeneration by activating pro-repair macrophages. However, the precise signaling governing this crosstalk upon injury is elusive. Here, using a mouse model of endovascular injury and single-cell RNA sequencing, the authors identify an IL-33–ST2–OPN axis that orchestrates the functional interaction between MSCs and reparative ST2+ macrophages, stimulating vascular smooth muscle cell and vascular repair.
- 作者:NotionNext
- 链接:https://tangly1024.com/article/31c48bd6-1f96-8153-b1f1-d2bf8040bcdd
- 声明:本文采用 CC BY-NC-SA 4.0 许可协议，转载请注明出处。
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