category
bioRxiv
date
Mar 14, 2026
slug
status
Published
summary
提出用户友好的snakemake工作流程,通过可视化反馈指导参数优化;证明仅使用HiFi读数即可获得高质量基因组组装,显著降低时间和资源投入。
tags
测序技术
type
Post

📄 原文题目

HiFi-Helper: A reproducible workflow for genome assembly from HiFi reads alone

🔗 原文链接

💡 AI 核心解读

提出用户友好的snakemake工作流程,通过可视化反馈指导参数优化;证明仅使用HiFi读数即可获得高质量基因组组装,显著降低时间和资源投入。

📝 英文原版摘要

The PacBio Revio simplifies genome assembly by generating very long reads with very few errors at an affordable price point. Comparative ease of assembly is democratizing access, leading to a larger niche for assembly workflows. HiFi-Helper is a user-friendly snakemake workflow designed to facilitate genome assembly from HiFi data alone. This tool produces a visual summary that provides intuitive feedback on the quality of the resulting assembly and guides assembly parameter optimization. The case studies presented here confirm that HiFi-only assemblies produced by HiFi-helper can meet or exceed the quality of genomes assembled in prior decades with a much lower investment of time and resources.
左心房结扎模型中左心发育不全综合征心脏神经嵴迁移模式的改变stMCP:基于模型上下文协议服务器的空间转录组学
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