category
Nature BME
date
Feb 11, 2026
slug
status
Published
summary
通过基因编辑技术敲除CAR T细胞中的两个PGE2受体，消除其信号传导途径，显著提升CAR T细胞在实体瘤微环境中抗肿瘤活性，该策略在体外实验、小鼠模型和患者来源的类器官模型中均验证有效。
tags
基因编辑
type
Post
📄 原文题目
Ablation of prostaglandin E<sub>2</sub> signalling through dual receptor knockout in CAR T cells enhances therapeutic efficacy in solid tumours
🔗 原文链接
💡 AI 核心解读
通过基因编辑技术敲除CAR T细胞中的两个PGE2受体，消除其信号传导途径，显著提升CAR T细胞在实体瘤微环境中抗肿瘤活性，该策略在体外实验、小鼠模型和患者来源的类器官模型中均验证有效。
📝 英文原版摘要
<p>Nature Biomedical Engineering, Published online: 11 February 2026; <a href="https://www.nature.com/articles/s41551-025-01610-6">doi:10.1038/s41551-025-01610-6</a></p>Targeted ablation of prostaglandin E2 (PGE2) signalling in CAR T cells enhances their activity in PGE2-rich solid tumours, with demonstrations of efficacy in vitro, in mouse xenografts and in patient-derived organotypic tumour spheroids.
- 作者:NotionNext
- 链接:https://tangly1024.com/article/30548bd6-1f96-81c1-8407-dd08a4380848
- 声明:本文采用 CC BY-NC-SA 4.0 许可协议，转载请注明出处。
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